Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test
نویسندگان
چکیده
Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted by assessing the concentration of serum anticetuximab immunoglobulin (Ig)E. The anticetuximab IgE concentration could be an interesting test to predict which patients are at risk of experiencing severe hypersensitivity reactions to cetuximab.
منابع مشابه
Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discove...
متن کاملA novel approach to predict cetuximab‐induced hypersensitivity reaction: detection of drug‐specific IgE on basophils
Cetuximab is remarkable for the relatively high rate and severity of hypersensitivity reactions (HR) being reported in the literature. Screening for cetuximab-specific IgE in serum via immunoassay has been found to be useful in preventing HR; however, these tests are known to have a low positive predictive rate. In an attempt to remedy this, we evaluated the interaction between cetuximab and Ig...
متن کاملINGUINAL HYDATID CYST: REPORT OF A RARE CASE
Hydatid cyst, the larval stage of Echinococcus spp., is a common parasitic disease in Iran. The liver and the lungs are the most commonly involved organs. Hydatid cysts have also been reported in bones and soft tissues such as muscle, brain tissue, spleen, thyroid and even in the heart. Hydatid cyst of the inguinal area, resembling a hernia is a rarity presenting at an unusual site. A hyper...
متن کاملPyogenic Liver Abscess as a Fatal Complication of Colonoscopy: a case report
Background: Colonoscopy is a safe and routinely-performed diagnostic and screening procedure for different colorectal diseases. The diagnostic and screening colonoscopy for is different for colon diseases. In order for colonoscopy, colon cleansing is required to prepare a detailed view into the intestinal lumen. Aim: This is a case report study of a patient with multiple pyogenic liver abscesse...
متن کاملThe Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test reve...
متن کامل